General Information of the Compound
Compound ID
CP0867572
Compound Name
(7aS,8S,10aR)-7a-Methyl-2-oxo-2,3,4,6,7,7a,8,9,10,10a,11,12-dodecahydro-indeno[4,5-c]quinolizine-8-carboxylic acid tert-butylamide; compound with (7aS,8S,10aS)-7a-methyl-2-oxo-2,3,4,7,7a,8,9,10,10a,10b,11,12-dodecahydro-indeno[4,5-c]quinolizine-8-carboxylic acid tert-butylamide
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Structure
Formula
C44H64N4O4
Molecular Weight
713.02
Canonical SMILES
CC(C)(C)NC(=O)[C@H]1CC[C@H]2C3=C(CC[C@]12C)N1CCC(=O)C=C1CC3.CC(C)(C)NC(=O)[C@H]1CC[C@H]2C3CCC4=CC(=O)CCN4C3=CC[C@]12C
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InChI
InChI=1S/2C22H32N2O2/c2*1-21(2,3)23-20(26)18-8-7-17-16-6-5-14-13-15(25)10-12-24(14)19(16)9-11-22(17,18)4/h13,17-18H,5-12H2,1-4H3,(H,23,26);9,13,16-18H,5-8,10-12H2,1-4H3,(H,23,26)/t17-,18+,22-;16?,17-,18+,22-/m00/s1
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InChIKey
WKDPWJCYKLSYEJ-KAKSCKKLSA-N
Physicochemical Property
logP
7.7239
Rotatable Bonds
2
Heavy Atom Count
52
Polar Areas
98.82
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
52

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 49859760
ChEMBL ID
CHEMBL1201841
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01430, 3-oxo-5-alpha-steroid 4-dehydrogenase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000119 DU145 Homo sapiens (Human)  1
1
IC50 = 127 nM
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