General Information of the Compound
Compound ID
CP0859544
Compound Name
9-Carbamoyl-7-methyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinolin-7-ium (alpha-ergocriptine)
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Structure
Formula
C16H17N3O
Molecular Weight
267.332
Canonical SMILES
CN1C[C@H](C(N)=O)C=C2c3cccc4[nH]cc(c34)C[C@H]21
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InChI
InChI=1S/C16H17N3O/c1-19-8-10(16(17)20)5-12-11-3-2-4-13-15(11)9(7-18-13)6-14(12)19/h2-5,7,10,14,18H,6,8H2,1H3,(H2,17,20)/t10-,14-/m1/s1
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InChIKey
GENAHGKEFJLNJB-QMTHXVAHSA-N
CAS
478-94-4
Physicochemical Property
logP
1.5229
Rotatable Bonds
1
Heavy Atom Count
20
Polar Areas
62.12
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Complexity
20

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 442072
SID: 26690311
ChEMBL ID
CHEMBL227213
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00957, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000049 C6 Rattus norvegicus (Rat)  3
1
Kd = 0.62 nM
   TI
   LI
   LO
   TS
2
Kd = 1 nM
   TI
   LI
   LO
   TS
3
Kd = 2.8 nM
   TI
   LI
   LO
   TS