General Information of the Compound
Compound ID
CP0857263
Compound Name
1-(1-(2-((2-Azidoethyl)disulfanyl)ethyl)-1H-1,2,3-triazol-4-yl)-4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)butan-1-one trifluoroacetic acid
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Structure
Formula
C23H29ClF3N7O4S2
Molecular Weight
624.111
Canonical SMILES
O=C(O)C(F)(F)F.[N-]=[N+]=NCCSSCCn1cc(C(=O)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)nn1
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InChI
InChI=1S/C21H28ClN7O2S2.C2HF3O2/c22-18-5-3-17(4-6-18)21(31)7-11-28(12-8-21)10-1-2-20(30)19-16-29(27-25-19)13-15-33-32-14-9-24-26-23;3-2(4,5)1(6)7/h3-6,16,31H,1-2,7-15H2;(H,6,7)
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InChIKey
UUZUZLNDXNAKTF-UHFFFAOYSA-N
Physicochemical Property
logP
5.203
Rotatable Bonds
13
Heavy Atom Count
40
Polar Areas
157.31
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
10
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137659809
ChEMBL ID
CHEMBL4100263
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
Ki = 140 nM
   TI
   LI
   LO
   TS
2
Ki = 260 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 210 nM
   TI
   LI
   LO
   TS