General Information of the Compound
Compound ID
CP0857262
Compound Name
1-(4-(2-((2-Aminoethyl)disulfanyl)ethoxy)-3-methoxyphenethyl)-4-(4-chlorophenyl)piperidin-4-ol ditrifluoroacetic acid
    Show/Hide
Structure
Formula
C28H35ClF6N2O7S2
Molecular Weight
725.17
Canonical SMILES
COc1cc(CCN2CCC(O)(c3ccc(Cl)cc3)CC2)ccc1OCCSSCCN.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
    Show/Hide
InChI
InChI=1S/C24H33ClN2O3S2.2C2HF3O2/c1-29-23-18-19(2-7-22(23)30-15-17-32-31-16-11-26)8-12-27-13-9-24(28,10-14-27)20-3-5-21(25)6-4-20;2*3-2(4,5)1(6)7/h2-7,18,28H,8-17,26H2,1H3;2*(H,6,7)
    Show/Hide
InChIKey
VSRBQTZDUTXCJO-UHFFFAOYSA-N
Physicochemical Property
logP
5.8602
Rotatable Bonds
12
Heavy Atom Count
46
Polar Areas
142.55
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
9
Complexity
46

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 137632586
ChEMBL ID
CHEMBL4065455
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1500 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 390 nM
   TI
   LI
   LO
   TS