General Information of the Compound
Compound ID
CP0857261
Compound Name
1-(4-(3-((2-Aminoethyl)disulfanyl)propoxy)-3-methoxyphenethyl)-4-(4-chlorophenyl)piperidin-4-ol ditrifluoroacetic acid
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Structure
Formula
C29H37ClF6N2O7S2
Molecular Weight
739.197
Canonical SMILES
COc1cc(CCN2CCC(O)(c3ccc(Cl)cc3)CC2)ccc1OCCCSSCCN.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
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InChI
InChI=1S/C25H35ClN2O3S2.2C2HF3O2/c1-30-24-19-20(3-8-23(24)31-16-2-17-32-33-18-12-27)9-13-28-14-10-25(29,11-15-28)21-4-6-22(26)7-5-21;2*3-2(4,5)1(6)7/h3-8,19,29H,2,9-18,27H2,1H3;2*(H,6,7)
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InChIKey
GGQVWQXOXKHXLB-UHFFFAOYSA-N
Physicochemical Property
logP
6.2503
Rotatable Bonds
13
Heavy Atom Count
47
Polar Areas
142.55
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
9
Complexity
47

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137648359
ChEMBL ID
CHEMBL4082245
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
Ki = 940 nM
   TI
   LI
   LO
   TS
2
Ki = 1000 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 600 nM
   TI
   LI
   LO
   TS