General Information of the Compound
Compound ID
CP0853881
Compound Name
4-(4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl)-1-(4-(2-((2-hydroxyethyl)disulfanyl)ethoxy)phenyl)butan-1-one formic acid
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Structure
Formula
C26H34ClNO6S2
Molecular Weight
556.146
Canonical SMILES
O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(OCCSSCCO)cc1.O=CO
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InChI
InChI=1S/C25H32ClNO4S2.CH2O2/c26-22-7-5-21(6-8-22)25(30)11-14-27(15-12-25)13-1-2-24(29)20-3-9-23(10-4-20)31-17-19-33-32-18-16-28;2-1-3/h3-10,28,30H,1-2,11-19H2;1H,(H,2,3)
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InChIKey
WPALLNAXHWNGCT-UHFFFAOYSA-N
Physicochemical Property
logP
4.7398
Rotatable Bonds
13
Heavy Atom Count
36
Polar Areas
107.3
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
8
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137642921
ChEMBL ID
CHEMBL4086894
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
Ki = 73 nM
   TI
   LI
   LO
   TS
2
Ki = 240 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 140 nM
   TI
   LI
   LO
   TS