General Information of the Compound
Compound ID
CP0800202
Compound Name
N-{1-[4-((S)-2,6-bis-dimethylamino-hexanoyl)-piperazine-1-carbonyl]-cyclopentyl}-2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonamide
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Structure
Formula
C38H52Cl2N6O5S
Molecular Weight
775.844
Canonical SMILES
Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCCCN(C)C)N(C)C)CC5)CCCC4)c3Cl)c2n1
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InChI
InChI=1S/C38H52Cl2N6O5S/c1-26-24-27(2)41-35-28(26)12-11-14-32(35)51-25-29-30(39)15-16-33(34(29)40)52(49,50)42-38(17-8-9-18-38)37(48)46-22-20-45(21-23-46)36(47)31(44(5)6)13-7-10-19-43(3)4/h11-12,14-16,24,31,42H,7-10,13,17-23,25H2,1-6H3/t31-/m0/s1
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InChIKey
SYZOYEODDGOCTH-HKBQPEDESA-N
Physicochemical Property
logP
5.66144
Rotatable Bonds
14
Heavy Atom Count
52
Polar Areas
115.39
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
52

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11766718
ChEMBL ID
CHEMBL374272
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02392, B2 bradykinin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000389 CHO-DXB11 Cricetulus griseus (Chinese hamster)  1
1
Kd = 3.162 nM
   TI
   LI
   LO
   TS
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 0.1995 nM
   TI
   LI
   LO
   TS