General Information of the Compound
Compound ID
CP0800200
Compound Name
2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-{1-[4-(6-guanidino-hexanoyl)-piperazine-1-carbonyl]-cyclopentyl}-benzenesulfonamide
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Structure
Formula
C35H45Cl2N7O5S
Molecular Weight
746.762
Canonical SMILES
Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCCNC(=N)N)CC5)CCCC4)c3Cl)c2n1
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InChI
InChI=1S/C35H45Cl2N7O5S/c1-23-21-24(2)41-32-25(23)9-8-10-28(32)49-22-26-27(36)12-13-29(31(26)37)50(47,48)42-35(14-5-6-15-35)33(46)44-19-17-43(18-20-44)30(45)11-4-3-7-16-40-34(38)39/h8-10,12-13,21,42H,3-7,11,14-20,22H2,1-2H3,(H4,38,39,40)
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InChIKey
BQIHVDDBUCQADT-UHFFFAOYSA-N
Physicochemical Property
logP
5.04281
Rotatable Bonds
13
Heavy Atom Count
50
Polar Areas
170.81
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
7
Complexity
50

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10441194
ChEMBL ID
CHEMBL222156
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02392, B2 bradykinin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000389 CHO-DXB11 Cricetulus griseus (Chinese hamster)  1
1
Kd = 1.995 nM
   TI
   LI
   LO
   TS
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1.259 nM
   TI
   LI
   LO
   TS