General Information of the Compound
Compound ID
CP0790468
Compound Name
17-(1-Hydroxyimino-ethyl)-10,13-dimethyl-1,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-2H-cyclopenta[a]phenanthrene-3,6-dione
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Structure
Formula
C21H29NO3
Molecular Weight
343.467
Canonical SMILES
C/C(=N/O)[C@H]1CCC2C3CC(=O)C4=CC(=O)CCC4(C)C3CCC21C
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InChI
InChI=1S/C21H29NO3/c1-12(22-25)15-4-5-16-14-11-19(24)18-10-13(23)6-8-21(18,3)17(14)7-9-20(15,16)2/h10,14-17,25H,4-9,11H2,1-3H3/b22-12-/t14?,15-,16?,17?,20?,21?/m1/s1
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InChIKey
SLYPLXIICAIYLS-JCASMQIKSA-N
Physicochemical Property
logP
4.1636
Rotatable Bonds
1
Heavy Atom Count
25
Polar Areas
66.73
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44356349
ChEMBL ID
CHEMBL344363
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01430, 3-oxo-5-alpha-steroid 4-dehydrogenase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000119 DU145 Homo sapiens (Human)  1
1
IC50 > 10000 nM
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