General Information of the Compound
Compound ID
CP0720693
Compound Name
N-{2-[4-((S)-2-amino-5-(dimethylamino)pentanoyl)piperazin-1-yl]-1,1-dimethyl-2-oxoethyl}-2,4-dichloro-3-(2,4-dimethylquinolin-8-yloxymethyl)benzenesulfonamide
    Show/Hide
Structure
Formula
C33H44Cl2N6O5S
Molecular Weight
707.725
Canonical SMILES
Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1
    Show/Hide
InChI
InChI=1S/C33H44Cl2N6O5S/c1-21-19-22(2)37-30-23(21)9-7-11-27(30)46-20-24-25(34)12-13-28(29(24)35)47(44,45)38-33(3,4)32(43)41-17-15-40(16-18-41)31(42)26(36)10-8-14-39(5)6/h7,9,11-13,19,26,38H,8,10,14-18,20,36H2,1-6H3/t26-/m0/s1
    Show/Hide
InChIKey
FWEDCBJKAGZGPE-SANMLTNESA-N
Physicochemical Property
logP
4.13424
Rotatable Bonds
12
Heavy Atom Count
47
Polar Areas
138.17
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
47

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 10101294
SID: 15088688
ChEMBL ID
CHEMBL380273
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02392, B2 bradykinin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000389 CHO-DXB11 Cricetulus griseus (Chinese hamster)  1
1
Kd = 0.7943 nM
   TI
   LI
   LO
   TS
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
Kd = 0.7943 nM
   TI
   LI
   LO
   TS
2
Ki = 0.3981 nM
   TI
   LI
   LO
   TS