General Information of the Compound
| Compound ID |
CP0674919
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| Compound Name |
(Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-2,3-dihydro-1H-indole-6-carboxylic Acid Amide
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| Formula |
C28H28N4O2
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| Molecular Weight |
452.558
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| Canonical SMILES |
NC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN2CCCCC2)cc1)c1ccccc1
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| InChI |
InChI=1S/C28H28N4O2/c29-27(33)21-11-14-23-24(17-21)31-28(34)25(23)26(20-7-3-1-4-8-20)30-22-12-9-19(10-13-22)18-32-15-5-2-6-16-32/h1,3-4,7-14,17,30H,2,5-6,15-16,18H2,(H2,29,33)(H,31,34)/b26-25-
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| InChIKey |
XZPCSXAQYZGHKR-QPLCGJKRSA-N
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| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
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Map of Molecular Bioactivity Related to the Compound
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Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01221, TGF-beta receptor type-1
Protein ID: PT00864, Vascular endothelial growth factor receptor 2
Cell Viability or Cytotoxicity Assay
| Cell Line ID | Cell Line Name | Cell Line Organism | |
| CL000749 | HUVEC-C | Homo sapiens (Human) | 1 |
| 1 |
EC50 = 342 nM
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