General Information of the Compound
Compound ID
CP0645518
Compound Name
ethyl 2-amino-6-methyl-4-(1-cyano-2-ethoxy-2-oxoethyl)-4Hchromene-3-carboxylate
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Structure
Formula
C18H20N2O5
Molecular Weight
344.367
Canonical SMILES
CCOC(=O)C1=C(N)Oc2ccc(C)cc2C1C(C#N)C(=O)OCC
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InChI
InChI=1S/C18H20N2O5/c1-4-23-17(21)12(9-19)14-11-8-10(3)6-7-13(11)25-16(20)15(14)18(22)24-5-2/h6-8,12,14H,4-5,20H2,1-3H3
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InChIKey
TUBRNFIFFYPWSN-UHFFFAOYSA-N
Physicochemical Property
logP
1.9073
Rotatable Bonds
5
Heavy Atom Count
25
Polar Areas
111.64
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 16098789
SID: 24745397
ChEMBL ID
CHEMBL220350
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01216, Apoptosis regulator Bcl-2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000001 Jurkat Homo sapiens (Human)  1
1
GI50 = 37000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01217, Bcl-2-like protein 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000001 Jurkat Homo sapiens (Human)  1
1
GI50 = 41000 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000001 Jurkat Homo sapiens (Human)  1
1
GI50 = 29000 nM
   TI
   LI
   LO
   TS