General Information of the Compound
Compound ID
CP0579976
Compound Name
9-[(3S)-1-(2-hydroxyethyl)pyrrolidin-3-yl]-7-methyl-2-[(7-methylquinolin-6-yl)amino]purin-8-one
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Structure
Formula
C22H25N7O2
Molecular Weight
419.489
Canonical SMILES
Cc1cc2ncccc2cc1Nc1ncc2n(C)c(=O)n([C@H]3CCN(CCO)C3)c2n1
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InChI
InChI=1S/C22H25N7O2/c1-14-10-18-15(4-3-6-23-18)11-17(14)25-21-24-12-19-20(26-21)29(22(31)27(19)2)16-5-7-28(13-16)8-9-30/h3-4,6,10-12,16,30H,5,7-9,13H2,1-2H3,(H,24,25,26)/t16-/m0/s1
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InChIKey
JYWGQRICHVVQIJ-INIZCTEOSA-N
Physicochemical Property
logP
1.96932
Rotatable Bonds
5
Heavy Atom Count
31
Polar Areas
101.1
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168284526
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00955, DNA-dependent protein kinase catalytic subunit
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549 Homo sapiens (Human)  1
1
IC50 = 142 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.75 nM
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 30000 nM
   TI
   LI
   LO
   TS