General Information of the Compound
Compound ID
CP0577769
Compound Name
US9249096, 229
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Structure
Formula
C16H18Cl2N2O3
Molecular Weight
357.237
Canonical SMILES
CC(CCc1ccc(Cl)c(Cl)c1)NC(=O)C1=C(O)C(=O)N(C)C1
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InChI
InChI=1S/C16H18Cl2N2O3/c1-9(3-4-10-5-6-12(17)13(18)7-10)19-15(22)11-8-20(2)16(23)14(11)21/h5-7,9,21H,3-4,8H2,1-2H3,(H,19,22)
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InChIKey
ZXENUOPVCDPWKD-UHFFFAOYSA-N
Physicochemical Property
logP
2.7148
Rotatable Bonds
5
Heavy Atom Count
23
Polar Areas
69.64
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
3
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 89489419
ChEMBL ID
CHEMBL3906595
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01303, Endothelial lipase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000156 HT-1080 Homo sapiens (Human)  1
1
IC50 = 4549 nM
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