General Information of the Compound
Compound ID
CP0577275
Compound Name
US9428456, 1.353
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Structure
Formula
C25H30N4O2S
Molecular Weight
450.608
Canonical SMILES
CC(C)(C)NC(=O)C1CCN(Cc2cccc(NC(=O)c3ccc4ncsc4c3)c2)CC1
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InChI
InChI=1S/C25H30N4O2S/c1-25(2,3)28-24(31)18-9-11-29(12-10-18)15-17-5-4-6-20(13-17)27-23(30)19-7-8-21-22(14-19)32-16-26-21/h4-8,13-14,16,18H,9-12,15H2,1-3H3,(H,27,30)(H,28,31)
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InChIKey
YBTVHBLUYVGUAH-UHFFFAOYSA-N
Physicochemical Property
logP
4.6753
Rotatable Bonds
5
Heavy Atom Count
32
Polar Areas
74.33
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118521936
ChEMBL ID
CHEMBL3949928
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04108, Atypical chemokine receptor 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000857 PathHunter CHO-K1 CXCR7 beta-arrestin Cricetulus griseus (Chinese hamster)  1
1
EC50 = 3 nM
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