General Information of the Compound
Compound ID
CP0576542
Compound Name
2-[4-[[3-[4-(cyclopropylmethoxy)phenyl]phenyl]methoxy]-2-fluorophenoxy]acetic acid
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Structure
Formula
C25H23FO5
Molecular Weight
422.452
Canonical SMILES
OC(=O)COc1ccc(OCc2cccc(c2)-c2ccc(OCC3CC3)cc2)cc1F
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InChI
InChI=1S/C25H23FO5/c26-23-13-22(10-11-24(23)31-16-25(27)28)30-15-18-2-1-3-20(12-18)19-6-8-21(9-7-19)29-14-17-4-5-17/h1-3,6-13,17H,4-5,14-16H2,(H,27,28)
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InChIKey
FOJUJKWUPWKPPX-UHFFFAOYSA-N
Physicochemical Property
logP
5.3239
Rotatable Bonds
10
Heavy Atom Count
31
Polar Areas
64.99
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168281295
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02793, Free fatty acid receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 540 nM
   TI
   LI
   LO
   TS
Protein ID: PT00909, Peroxisome proliferator-activated receptor delta
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 540 nM
   TI
   LI
   LO
   TS