General Information of the Compound
Compound ID
CP0570012
Compound Name
[(2R,3S,4R,5R)-5-[2-chloro-6-(cyclopentylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methoxymethylphosphonic acid
    Show/Hide
Structure
Formula
C16H23ClN5O7P
Molecular Weight
463.815
Canonical SMILES
O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COCP(O)(O)=O)n1cnc2c(NC3CCCC3)nc(Cl)nc12
    Show/Hide
InChI
InChI=1S/C16H23ClN5O7P/c17-16-20-13(19-8-3-1-2-4-8)10-14(21-16)22(6-18-10)15-12(24)11(23)9(29-15)5-28-7-30(25,26)27/h6,8-9,11-12,15,23-24H,1-5,7H2,(H,19,20,21)(H2,25,26,27)/t9-,11-,12-,15-/m1/s1
    Show/Hide
InChIKey
ALDWNWOVOJESRL-SDBHATRESA-N
Physicochemical Property
logP
0.6052
Rotatable Bonds
7
Heavy Atom Count
30
Polar Areas
172.08
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
10
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 139481758
ChEMBL ID
CHEMBL4791637
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03381, 5'-nucleotidase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 26 nM
   TI
   LI
   LO
   TS