General Information of the Compound
Compound ID
CP0568962
Compound Name
N-[4-(4-butanoyl-5-methylpyrazol-1-yl)-2-carbamoylphenyl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]indole-3-carboxamide
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Structure
Formula
C31H34ClN7O4
Molecular Weight
604.111
Canonical SMILES
CCCC(=O)c1cnn(c1C)-c1ccc(NC(=O)c2cn(CC(=O)N3CCN(C)CC3)c3ccc(Cl)cc23)c(c1)C(N)=O
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InChI
InChI=1S/C31H34ClN7O4/c1-4-5-28(40)24-16-34-39(19(24)2)21-7-8-26(23(15-21)30(33)42)35-31(43)25-17-38(27-9-6-20(32)14-22(25)27)18-29(41)37-12-10-36(3)11-13-37/h6-9,14-17H,4-5,10-13,18H2,1-3H3,(H2,33,42)(H,35,43)
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InChIKey
NGVGPDQUAMGXTG-UHFFFAOYSA-N
Physicochemical Property
logP
3.89682
Rotatable Bonds
9
Heavy Atom Count
43
Polar Areas
135.56
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118711249
ChEMBL ID
CHEMBL3325898
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02449, P2Y purinoceptor 12
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 266 nM
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