General Information of the Compound
Compound ID
CP0566451
Compound Name
(5-amino-3,4-dimethylthieno[2,3-c]pyridazin-6-yl)-(2,4-difluorophenyl)methanol
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Structure
Formula
C15H13F2N3OS
Molecular Weight
321.352
Canonical SMILES
Cc1nnc2sc(C(O)c3ccc(F)cc3F)c(N)c2c1C
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InChI
InChI=1S/C15H13F2N3OS/c1-6-7(2)19-20-15-11(6)12(18)14(22-15)13(21)9-4-3-8(16)5-10(9)17/h3-5,13,21H,18H2,1-2H3
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InChIKey
IONUCYUTLQPLSH-UHFFFAOYSA-N
Physicochemical Property
logP
3.25024
Rotatable Bonds
2
Heavy Atom Count
22
Polar Areas
72.03
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
22

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155542543
ChEMBL ID
CHEMBL4521280
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01156, Muscarinic acetylcholine receptor M4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01736, Muscarinic acetylcholine receptor M4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS