General Information of the Compound
Compound ID
CP0565775
Compound Name
4-(4-cyanophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperazine-1-carboxamide
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Structure
Formula
C33H42N8O2
Molecular Weight
582.753
Canonical SMILES
Cc1cc(C[C@@H](NC(=O)N2CCN(CC2)c2ccc(cc2)C#N)C(=O)N2CCC(CC2)N2CCCCC2)cc2cn[nH]c12
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InChI
InChI=1S/C33H42N8O2/c1-24-19-26(20-27-23-35-37-31(24)27)21-30(32(42)40-13-9-29(10-14-40)38-11-3-2-4-12-38)36-33(43)41-17-15-39(16-18-41)28-7-5-25(22-34)6-8-28/h5-8,19-20,23,29-30H,2-4,9-18,21H2,1H3,(H,35,37)(H,36,43)/t30-/m1/s1
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InChIKey
IZLMITUIMKEMIX-SSEXGKCCSA-N
Physicochemical Property
logP
3.6628
Rotatable Bonds
6
Heavy Atom Count
43
Polar Areas
111.6
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 127027807
ChEMBL ID
CHEMBL3771287
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04285, Calcitonin gene-related peptide 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  1
1
IC50 = 99 nM
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