General Information of the Compound
Compound ID
CP0565681
Compound Name
US8791272, 14.6
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Structure
Formula
C22H24N2O3
Molecular Weight
364.445
Canonical SMILES
CC(Oc1ccccc1)c1ccc(Cn2nc(C)c(CC(O)=O)c2C)cc1
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InChI
InChI=1S/C22H24N2O3/c1-15-21(13-22(25)26)16(2)24(23-15)14-18-9-11-19(12-10-18)17(3)27-20-7-5-4-6-8-20/h4-12,17H,13-14H2,1-3H3,(H,25,26)
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InChIKey
LILTTWRIOILJMB-UHFFFAOYSA-N
Physicochemical Property
logP
4.31534
Rotatable Bonds
7
Heavy Atom Count
27
Polar Areas
64.35
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 58071750
ChEMBL ID
CHEMBL3686044
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01171, Prostaglandin D2 receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000602 ValiScreen human CRTH2 Cricetulus griseus (Chinese hamster)  1
1
Ki = 428 nM
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