General Information of the Compound
Compound ID
CP0564911
Compound Name
6-(1-methylsulfonylpiperidin-4-yl)oxy-N-[1-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)piperidin-4-yl]-N-(trifluoromethyl)pyrimidin-4-amine
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Formula
C21H30F3N7O4S
Molecular Weight
533.577
Canonical SMILES
CC(C)c1noc(n1)N1CCC(CC1)N(c1cc(OC2CCN(CC2)S(C)(=O)=O)ncn1)C(F)(F)F
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InChI
InChI=1S/C21H30F3N7O4S/c1-14(2)19-27-20(35-28-19)29-8-4-15(5-9-29)31(21(22,23)24)17-12-18(26-13-25-17)34-16-6-10-30(11-7-16)36(3,32)33/h12-16H,4-11H2,1-3H3
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InChIKey
LPLPNJWCCCXUQU-UHFFFAOYSA-N
Physicochemical Property
logP
2.781
Rotatable Bonds
7
Heavy Atom Count
36
Polar Areas
117.79
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
10
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4851479
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02455, Glucose-dependent insulinotropic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 2.7 nM
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