General Information of the Compound
Compound ID
CP0561607
Compound Name
US9458135, 29
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Structure
Formula
C23H20ClN3O2
Molecular Weight
405.885
Canonical SMILES
CN1C(=O)CCc2cc(ccc12)-c1cncc(CC(=O)Nc2cccc(Cl)c2)c1
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InChI
InChI=1S/C23H20ClN3O2/c1-27-21-7-5-16(11-17(21)6-8-23(27)29)18-9-15(13-25-14-18)10-22(28)26-20-4-2-3-19(24)12-20/h2-5,7,9,11-14H,6,8,10H2,1H3,(H,26,28)
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InChIKey
ROAMWIZUESYNFI-UHFFFAOYSA-N
Physicochemical Property
logP
4.4922
Rotatable Bonds
4
Heavy Atom Count
29
Polar Areas
62.3
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 78320872
ChEMBL ID
CHEMBL3900120
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03119, Cytochrome P450 11B1, mitochondrial
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000405 G-402 Homo sapiens (Human)  1
1
EC50 = 306.6 nM
   TI
   LI
   LO
   TS
Protein ID: PT03120, Cytochrome P450 11B2, mitochondrial
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000405 G-402 Homo sapiens (Human)  1
1
EC50 = 12.7 nM
   TI
   LI
   LO
   TS