General Information of the Compound
Compound ID
CP0560981
Compound Name
US9139578, 7
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Structure
Formula
C23H18F2N8O4S2
Molecular Weight
572.579
Canonical SMILES
NS(=O)(=O)NCc1nnc(o1)C(NC(=O)Nc1ccc(F)cc1)c1nc2ccc(cc2s1)-c1ccc(F)nc1
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InChI
InChI=1S/C23H18F2N8O4S2/c24-14-3-5-15(6-4-14)29-23(34)31-20(21-33-32-19(37-21)11-28-39(26,35)36)22-30-16-7-1-12(9-17(16)38-22)13-2-8-18(25)27-10-13/h1-10,20,28H,11H2,(H2,26,35,36)(H2,29,31,34)
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InChIKey
TUHLTTPOEXVXFA-UHFFFAOYSA-N
Physicochemical Property
logP
3.2237
Rotatable Bonds
8
Heavy Atom Count
39
Polar Areas
178.02
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
9
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 72947754
ChEMBL ID
CHEMBL3892844
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01303, Endothelial lipase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000156 HT-1080 Homo sapiens (Human)  1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS