General Information of the Compound
Compound ID
CP0560093
Compound Name
2-[1-[6-[1-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)piperidin-4-yl]oxypyrimidin-4-yl]-2,3-dihydroindol-5-yl]-1,2,6-thiadiazinane 1,1-dioxide
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Formula
C25H32N8O4S
Molecular Weight
540.65
Canonical SMILES
CC(C)c1noc(n1)N1CCC(CC1)Oc1cc(ncn1)N1CCc2cc(ccc12)N1CCCNS1(=O)=O
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InChI
InChI=1S/C25H32N8O4S/c1-17(2)24-29-25(37-30-24)31-11-7-20(8-12-31)36-23-15-22(26-16-27-23)32-13-6-18-14-19(4-5-21(18)32)33-10-3-9-28-38(33,34)35/h4-5,14-17,20,28H,3,6-13H2,1-2H3
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InChIKey
CFABNFPFYHNDOQ-UHFFFAOYSA-N
Physicochemical Property
logP
2.7695
Rotatable Bonds
6
Heavy Atom Count
38
Polar Areas
129.82
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
10
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4763323
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02455, Glucose-dependent insulinotropic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 24 nM
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