General Information of the Compound
Compound ID
CP0557880
Compound Name
US9206164, 23
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Structure
Formula
C24H22Cl2N4O2
Molecular Weight
469.372
Canonical SMILES
CCc1nn(Cc2ccc(cc2)-c2nc3cc(Cl)c(Cl)cc3[nH]2)c(C2CC2)c1CC(O)=O
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InChI
InChI=1S/C24H22Cl2N4O2/c1-2-19-16(9-22(31)32)23(14-7-8-14)30(29-19)12-13-3-5-15(6-4-13)24-27-20-10-17(25)18(26)11-21(20)28-24/h3-6,10-11,14H,2,7-9,12H2,1H3,(H,27,28)(H,31,32)
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InChIKey
LEEKSBLIWOYKOT-UHFFFAOYSA-N
Physicochemical Property
logP
5.8484
Rotatable Bonds
7
Heavy Atom Count
32
Polar Areas
83.8
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 66550937
SID: 152143611
ChEMBL ID
CHEMBL3971441
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01171, Prostaglandin D2 receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000602 ValiScreen human CRTH2 Cricetulus griseus (Chinese hamster)  1
1
Ki = 41.1 nM
   TI
   LI
   LO
   TS