General Information of the Compound
Compound ID
CP0557005
Compound Name
US9169240, 59
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Structure
Formula
C24H17FN4O2S
Molecular Weight
444.491
Canonical SMILES
Fc1ccc(cc1)-c1ccc2nc(sc2c1)C(=O)c1nnc(NCCc2ccccc2)o1
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InChI
InChI=1S/C24H17FN4O2S/c25-18-9-6-16(7-10-18)17-8-11-19-20(14-17)32-23(27-19)21(30)22-28-29-24(31-22)26-13-12-15-4-2-1-3-5-15/h1-11,14H,12-13H2,(H,26,29)
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InChIKey
DFXCPTHPJKXZMY-UHFFFAOYSA-N
Physicochemical Property
logP
5.371
Rotatable Bonds
7
Heavy Atom Count
32
Polar Areas
80.91
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118322813
ChEMBL ID
CHEMBL3947398
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01303, Endothelial lipase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000156 HT-1080 Homo sapiens (Human)  1
1
IC50 = 49 nM
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