General Information of the Compound
Compound ID
CP0556494
Compound Name
S-propan-2-yl 4-[6-(2,3-dihydroindol-1-yl)pyrimidin-4-yl]oxypiperidine-1-carbothioate
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Formula
C21H26N4O2S
Molecular Weight
398.532
Canonical SMILES
CC(C)SC(=O)N1CCC(CC1)Oc1cc(ncn1)N1CCc2ccccc12
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InChI
InChI=1S/C21H26N4O2S/c1-15(2)28-21(26)24-10-8-17(9-11-24)27-20-13-19(22-14-23-20)25-12-7-16-5-3-4-6-18(16)25/h3-6,13-15,17H,7-12H2,1-2H3
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InChIKey
CISHLRPEHITLLC-UHFFFAOYSA-N
Physicochemical Property
logP
4.2756
Rotatable Bonds
4
Heavy Atom Count
28
Polar Areas
58.56
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4789349
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02455, Glucose-dependent insulinotropic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS