General Information of the Compound
Compound ID
CP0556138
Compound Name
(3R)-5-fluoro-3-hydroxy-3-[[4-([1,3]oxathiolo[5,4-c]pyridin-6-ylmethylamino)-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one
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Structure
Formula
C25H25FN4O4S
Molecular Weight
496.564
Canonical SMILES
O[C@@]1(CC23CCC(CC2)(CO3)NCc2cc3SCOc3cn2)Cn2c3c1c(F)cnc3ccc2=O
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InChI
InChI=1S/C25H25FN4O4S/c26-16-9-28-17-1-2-20(31)30-12-25(32,21(16)22(17)30)11-24-5-3-23(4-6-24,13-34-24)29-8-15-7-19-18(10-27-15)33-14-35-19/h1-2,7,9-10,29,32H,3-6,8,11-14H2/t23?,24?,25-/m0/s1
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InChIKey
TWCHXZZYURJWPC-STEQJIOHSA-N
Physicochemical Property
logP
2.8355
Rotatable Bonds
5
Heavy Atom Count
35
Polar Areas
98.5
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118736768
ChEMBL ID
CHEMBL3425932
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 33600 nM
   TI
   LI
   LO
   TS