General Information of the Compound
Compound ID
CP0556073
Compound Name
US8993557, 21
    Show/Hide
Structure
Formula
C20H18N2O3
Molecular Weight
334.375
Canonical SMILES
Cn1ccc(C(=O)NCc2cccc(c2)-c2ccccc2)c(O)c1=O
    Show/Hide
InChI
InChI=1S/C20H18N2O3/c1-22-11-10-17(18(23)20(22)25)19(24)21-13-14-6-5-9-16(12-14)15-7-3-2-4-8-15/h2-12,23H,13H2,1H3,(H,21,24)
    Show/Hide
InChIKey
CXRDRMBRNIIMJO-UHFFFAOYSA-N
Physicochemical Property
logP
2.6879
Rotatable Bonds
4
Heavy Atom Count
25
Polar Areas
71.33
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 90343428
ChEMBL ID
CHEMBL3696227
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01303, Endothelial lipase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000156 HT-1080 Homo sapiens (Human)  1
1
IC50 = 17.92 nM
   TI
   LI
   LO
   TS