General Information of the Compound
Compound ID
CP0547018
Compound Name
2-(pyridin-3-yloxymethyl)-N-[4-(trifluoromethyl)phenyl]piperazine-1-carboxamide;hydrochloride
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Structure
Formula
C18H19F3N4O2
Molecular Weight
380.37
Canonical SMILES
FC(F)(F)c1ccc(NC(=O)N2CCNCC2COc2cccnc2)cc1
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InChI
InChI=1S/C18H19F3N4O2.ClH/c19-18(20,21)13-3-5-14(6-4-13)24-17(26)25-9-8-23-10-15(25)12-27-16-2-1-7-22-11-16;/h1-7,11,15,23H,8-10,12H2,(H,24,26);1H
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InChIKey
BOJCWRSNIGYOSS-UHFFFAOYSA-N
Physicochemical Property
logP
2.9851
Rotatable Bonds
4
Heavy Atom Count
27
Polar Areas
66.49
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 90643567
ChEMBL ID
CHEMBL3262160
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02118, Neuronal acetylcholine receptor subunit alpha-7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000868 PC12 Rattus norvegicus (Rat)  1
1
IC50 = 220 nM
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