General Information of the Compound
Compound ID
CP0546690
Compound Name
US8791272, 9.28
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Structure
Formula
C26H26FN3O4
Molecular Weight
463.509
Canonical SMILES
CCc1nn(Cc2ccc(cc2F)C(=O)NCc2cc3ccccc3o2)c(CC)c1CC(O)=O
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InChI
InChI=1S/C26H26FN3O4/c1-3-22-20(13-25(31)32)23(4-2)30(29-22)15-18-10-9-17(12-21(18)27)26(33)28-14-19-11-16-7-5-6-8-24(16)34-19/h5-12H,3-4,13-15H2,1-2H3,(H,28,33)(H,31,32)
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InChIKey
WOKLKWPWQKKTDK-UHFFFAOYSA-N
Physicochemical Property
logP
4.4986
Rotatable Bonds
9
Heavy Atom Count
34
Polar Areas
97.36
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 58071770
ChEMBL ID
CHEMBL3686018
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01171, Prostaglandin D2 receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000602 ValiScreen human CRTH2 Cricetulus griseus (Chinese hamster)  1
1
Ki = 10.4 nM
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   LI
   LO
   TS