General Information of the Compound
Compound ID
CP0544461
Compound Name
(4S)-4-[[5-(2-cyclopropyl-2-oxoethoxy)-1-phenylpyrazole-3-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid
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Structure
Formula
C27H33N5O8
Molecular Weight
555.588
Canonical SMILES
CCOC(=O)N1CCN(CC1)C(=O)[C@H](CCC(O)=O)NC(=O)c1cc(OCC(=O)C2CC2)n(n1)-c1ccccc1
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InChI
InChI=1S/C27H33N5O8/c1-2-39-27(38)31-14-12-30(13-15-31)26(37)20(10-11-24(34)35)28-25(36)21-16-23(40-17-22(33)18-8-9-18)32(29-21)19-6-4-3-5-7-19/h3-7,16,18,20H,2,8-15,17H2,1H3,(H,28,36)(H,34,35)/t20-/m0/s1
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InChIKey
ORMSOLPCVAXNFM-FQEVSTJZSA-N
Physicochemical Property
logP
1.4941
Rotatable Bonds
12
Heavy Atom Count
40
Polar Areas
160.37
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 66919996
SID: 163456858
ChEMBL ID
CHEMBL2172280
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02449, P2Y purinoceptor 12
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 249 nM
   TI
   LI
   LO
   TS