General Information of the Compound
Compound ID
CP0540422
Compound Name
[6-(2-fluoroethoxy)pyridin-3-yl]-[1-[(2R,3R)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]piperidin-4-yl]methanone
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Structure
Formula
C23H27FN2O3
Molecular Weight
398.478
Canonical SMILES
O[C@@H]1Cc2ccccc2C[C@H]1N1CCC(CC1)C(=O)c1ccc(OCCF)nc1
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InChI
InChI=1S/C23H27FN2O3/c24-9-12-29-22-6-5-19(15-25-22)23(28)16-7-10-26(11-8-16)20-13-17-3-1-2-4-18(17)14-21(20)27/h1-6,15-16,20-21,27H,7-14H2/t20-,21-/m1/s1
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InChIKey
IVSNCPPNDXXHRP-NHCUHLMSSA-N
Physicochemical Property
logP
2.8529
Rotatable Bonds
6
Heavy Atom Count
29
Polar Areas
62.66
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 73347556
ChEMBL ID
CHEMBL2409375
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02273, Vesicular acetylcholine transporter
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000868 PC12 Rattus norvegicus (Rat)  1
1
Ki = 38 nM
   TI
   LI
   LO
   TS