General Information of the Compound
Compound ID
CP0537739
Compound Name
2-[1-[6-[1-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)piperidin-4-yl]oxypyrimidin-4-yl]-2,3-dihydroindol-5-yl]cyclohexan-1-one
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Formula
C28H34N6O3
Molecular Weight
502.619
Canonical SMILES
CC(C)c1noc(n1)N1CCC(CC1)Oc1cc(ncn1)N1CCc2cc(ccc12)C1CCCCC1=O
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InChI
InChI=1S/C28H34N6O3/c1-18(2)27-31-28(37-32-27)33-12-10-21(11-13-33)36-26-16-25(29-17-30-26)34-14-9-20-15-19(7-8-23(20)34)22-5-3-4-6-24(22)35/h7-8,15-18,21-22H,3-6,9-14H2,1-2H3
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InChIKey
PQKGSURDUWLIQB-UHFFFAOYSA-N
Physicochemical Property
logP
4.9517
Rotatable Bonds
6
Heavy Atom Count
37
Polar Areas
97.48
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
9
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4780567
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02455, Glucose-dependent insulinotropic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 48 nM
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