General Information of the Compound
Compound ID
CP0535227
Compound Name
(S)-4-(6-(4-(2-(ethylamino)-2-oxoethyl)piperidin-1-yl)-2-phenylpyrimidine-4-carboxamido)-5-oxo-5-(4-(pentyloxycarbonyl)piperazin-1-yl)pentanoic acid
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Structure
Formula
C35H49N7O7
Molecular Weight
679.819
Canonical SMILES
CCCCCOC(=O)N1CCN(CC1)C(=O)[C@H](CCC(O)=O)NC(=O)c1cc(nc(n1)-c1ccccc1)N1CCC(CC(=O)NCC)CC1
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InChI
InChI=1S/C35H49N7O7/c1-3-5-9-22-49-35(48)42-20-18-41(19-21-42)34(47)27(12-13-31(44)45)38-33(46)28-24-29(39-32(37-28)26-10-7-6-8-11-26)40-16-14-25(15-17-40)23-30(43)36-4-2/h6-8,10-11,24-25,27H,3-5,9,12-23H2,1-2H3,(H,36,43)(H,38,46)(H,44,45)/t27-/m0/s1
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InChIKey
KNAFSCAQXWZIFH-MHZLTWQESA-N
Physicochemical Property
logP
3.3204
Rotatable Bonds
15
Heavy Atom Count
49
Polar Areas
174.37
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
9
Complexity
49

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45485966
ChEMBL ID
CHEMBL565836
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02449, P2Y purinoceptor 12
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 0.67 nM
   TI
   LI
   LO
   TS