General Information of the Compound
Compound ID
CP0535160
Compound Name
N-[phenyl(pyridin-2-yl)methyl]-2-[1-[[1-[4-(trifluoromethyl)phenyl]pyrrol-3-yl]methyl]piperidin-4-yl]acetamide
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Structure
Formula
C31H31F3N4O
Molecular Weight
532.61
Canonical SMILES
FC(F)(F)c1ccc(cc1)-n1ccc(CN2CCC(CC(=O)NC(c3ccccc3)c3ccccn3)CC2)c1
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InChI
InChI=1S/C31H31F3N4O/c32-31(33,34)26-9-11-27(12-10-26)38-19-15-24(22-38)21-37-17-13-23(14-18-37)20-29(39)36-30(25-6-2-1-3-7-25)28-8-4-5-16-35-28/h1-12,15-16,19,22-23,30H,13-14,17-18,20-21H2,(H,36,39)
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InChIKey
UWQWKEPZJZVFAV-UHFFFAOYSA-N
Physicochemical Property
logP
6.399
Rotatable Bonds
8
Heavy Atom Count
39
Polar Areas
50.16
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11706443
SID: 16811114
ChEMBL ID
CHEMBL561585
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 41 nM
   TI
   LI
   LO
   TS
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 2300 nM
   TI
   LI
   LO
   TS