General Information of the Compound
Compound ID
CP0534432
Compound Name
1-(4-(pyrrolidine-1-carbonyl)piperazin-1-yl)-2-(1-((1-(4-(trifluoromethyl)phenyl)-1H-pyrrol-3-yl)methyl)piperidin-4-yl)ethanone
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Structure
Formula
C28H36F3N5O2
Molecular Weight
531.623
Canonical SMILES
FC(F)(F)c1ccc(cc1)-n1ccc(CN2CCC(CC(=O)N3CCN(CC3)C(=O)N3CCCC3)CC2)c1
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InChI
InChI=1S/C28H36F3N5O2/c29-28(30,31)24-3-5-25(6-4-24)36-14-9-23(21-36)20-32-12-7-22(8-13-32)19-26(37)33-15-17-35(18-16-33)27(38)34-10-1-2-11-34/h3-6,9,14,21-22H,1-2,7-8,10-13,15-20H2
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InChIKey
XPBAUQRKCOGQBD-UHFFFAOYSA-N
Physicochemical Property
logP
4.4582
Rotatable Bonds
5
Heavy Atom Count
38
Polar Areas
52.03
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45269996
ChEMBL ID
CHEMBL562905
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 417 nM
   TI
   LI
   LO
   TS
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 14000 nM
   TI
   LI
   LO
   TS