General Information of the Compound
Compound ID
CP0533474
Compound Name
tert-butyl 4-[[6-(1-methylsulfonylpiperidin-4-yl)oxypyrimidin-4-yl]-(trifluoromethyl)amino]piperidine-1-carboxylate
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Formula
C21H32F3N5O5S
Molecular Weight
523.578
Canonical SMILES
CC(C)(C)OC(=O)N1CCC(CC1)N(c1cc(OC2CCN(CC2)S(C)(=O)=O)ncn1)C(F)(F)F
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InChI
InChI=1S/C21H32F3N5O5S/c1-20(2,3)34-19(30)27-9-5-15(6-10-27)29(21(22,23)24)17-13-18(26-14-25-17)33-16-7-11-28(12-8-16)35(4,31)32/h13-16H,5-12H2,1-4H3
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InChIKey
ZYPAPWHZBZNCJX-UHFFFAOYSA-N
Physicochemical Property
logP
3.0051
Rotatable Bonds
5
Heavy Atom Count
35
Polar Areas
105.17
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
8
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4855738
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02455, Glucose-dependent insulinotropic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 3.6 nM
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