General Information of the Compound
Compound ID
CP0532032
Compound Name
tert-butyl 4-[methyl-[6-(5-methylsulfonyl-2,3-dihydroindol-1-yl)pyrimidin-4-yl]amino]piperidine-1-carboxylate
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Structure
Formula
C24H33N5O4S
Molecular Weight
487.626
Canonical SMILES
CN(C1CCN(CC1)C(=O)OC(C)(C)C)c1cc(ncn1)N1CCc2cc(ccc12)S(C)(=O)=O
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InChI
InChI=1S/C24H33N5O4S/c1-24(2,3)33-23(30)28-11-9-18(10-12-28)27(4)21-15-22(26-16-25-21)29-13-8-17-14-19(34(5,31)32)6-7-20(17)29/h6-7,14-16,18H,8-13H2,1-5H3
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InChIKey
BDWMCRCCWFPXMC-UHFFFAOYSA-N
Physicochemical Property
logP
3.41
Rotatable Bonds
4
Heavy Atom Count
34
Polar Areas
95.94
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
8
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 58116588
ChEMBL ID
CHEMBL4871114
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02455, Glucose-dependent insulinotropic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 21 nM
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