General Information of the Compound
Compound ID
CP0524150
Compound Name
(4S)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[6-(4-methylpiperazin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino]-5-oxopentanoic acid
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Structure
Formula
C28H37N7O6
Molecular Weight
567.647
Canonical SMILES
CCOC(=O)N1CCN(CC1)C(=O)[C@H](CCC(O)=O)NC(=O)c1cc(nc(n1)-c1ccccc1)N1CCN(C)CC1
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InChI
InChI=1S/C28H37N7O6/c1-3-41-28(40)35-17-15-34(16-18-35)27(39)21(9-10-24(36)37)30-26(38)22-19-23(33-13-11-32(2)12-14-33)31-25(29-22)20-7-5-4-6-8-20/h4-8,19,21H,3,9-18H2,1-2H3,(H,30,38)(H,36,37)/t21-/m0/s1
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InChIKey
IXKWTRVPQNASMZ-NRFANRHFSA-N
Physicochemical Property
logP
1.1593
Rotatable Bonds
9
Heavy Atom Count
41
Polar Areas
148.51
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118710241
ChEMBL ID
CHEMBL3322620
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02449, P2Y purinoceptor 12
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 46 nM
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