General Information of the Compound
Compound ID
CP0523992
Compound Name
(4S)-4-[({4-[(4-Acetylpiperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl}carbonyl)amino]-5-oxo-5-{4-[(pentyloxy)carbonyl]piperazin-1-yl}pentanoic Acid
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Structure
Formula
C34H44N6O8
Molecular Weight
664.76
Canonical SMILES
CCCCCOC(=O)N1CCN(CC1)C(=O)[C@H](CCC(O)=O)NC(=O)c1cc(cc(n1)-c1ccccc1)C(=O)N1CCN(CC1)C(C)=O
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InChI
InChI=1S/C34H44N6O8/c1-3-4-8-21-48-34(47)40-19-17-39(18-20-40)33(46)27(11-12-30(42)43)36-31(44)29-23-26(22-28(35-29)25-9-6-5-7-10-25)32(45)38-15-13-37(14-16-38)24(2)41/h5-7,9-10,22-23,27H,3-4,8,11-21H2,1-2H3,(H,36,44)(H,42,43)/t27-/m0/s1
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InChIKey
RKGPWMOFSGLAJD-MHZLTWQESA-N
Physicochemical Property
logP
2.4871
Rotatable Bonds
12
Heavy Atom Count
48
Polar Areas
169.76
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
48

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45140751
SID: 92390697
ChEMBL ID
CHEMBL590749
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02449, P2Y purinoceptor 12
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1.7 nM
   TI
   LI
   LO
   TS