General Information of the Compound
Compound ID
CP0522379
Compound Name
9-(3-(piperidin-1-yl)propoxy)-6-p-tolyl-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline
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Structure
Formula
C27H36N2O
Molecular Weight
404.598
Canonical SMILES
Cc1ccc(cc1)C1CN2CCCC2c2cc(OCCCN3CCCCC3)ccc12
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InChI
InChI=1S/C27H36N2O/c1-21-8-10-22(11-9-21)26-20-29-17-5-7-27(29)25-19-23(12-13-24(25)26)30-18-6-16-28-14-3-2-4-15-28/h8-13,19,26-27H,2-7,14-18,20H2,1H3
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InChIKey
SHAFCOFWNARKDQ-UHFFFAOYSA-N
Physicochemical Property
logP
5.53222
Rotatable Bonds
6
Heavy Atom Count
30
Polar Areas
15.71
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44438905
ChEMBL ID
CHEMBL240466
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01194, Histamine H3 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  2
1
Ki = 2 nM
   TI
   LI
   LO
   TS
2
Ki = 4.7 nM
   TI
   LI
   LO
   TS