General Information of the Compound
Compound ID
CP0522032
Compound Name
(4S)-4-{[(4-{[Methyl(1-methylpiperidin-4-yl)amino]carbonyl}-6-phenylpyridin-2-yl)carbonyl]amino}-5-oxo-5-{4-[(pentyloxy)-carbonyl]piperazin-1-yl}pentanoic Acid
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Structure
Formula
C35H48N6O7
Molecular Weight
664.804
Canonical SMILES
CCCCCOC(=O)N1CCN(CC1)C(=O)[C@H](CCC(O)=O)NC(=O)c1cc(cc(n1)-c1ccccc1)C(=O)N(C)C1CCN(C)CC1
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InChI
InChI=1S/C35H48N6O7/c1-4-5-9-22-48-35(47)41-20-18-40(19-21-41)34(46)28(12-13-31(42)43)37-32(44)30-24-26(23-29(36-30)25-10-7-6-8-11-25)33(45)39(3)27-14-16-38(2)17-15-27/h6-8,10-11,23-24,27-28H,4-5,9,12-22H2,1-3H3,(H,37,44)(H,42,43)/t28-/m0/s1
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InChIKey
RAOFKNNXPSVYPH-NDEPHWFRSA-N
Physicochemical Property
logP
3.349
Rotatable Bonds
13
Heavy Atom Count
48
Polar Areas
152.69
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
48

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45140164
SID: 92390107
ChEMBL ID
CHEMBL603151
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02449, P2Y purinoceptor 12
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 11 nM
   TI
   LI
   LO
   TS