General Information of the Compound
Compound ID
CP0520876
Compound Name
1-[[5-(5-ethylsulfonyl-2-methoxyphenyl)-1H-pyrrol-2-yl]methyl]-2-(3-methoxyphenyl)azepane
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Structure
Formula
C27H34N2O4S
Molecular Weight
482.646
Canonical SMILES
CCS(=O)(=O)c1ccc(OC)c(c1)-c1ccc(CN2CCCCCC2c2cccc(OC)c2)[nH]1
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InChI
InChI=1S/C27H34N2O4S/c1-4-34(30,31)23-13-15-27(33-3)24(18-23)25-14-12-21(28-25)19-29-16-7-5-6-11-26(29)20-9-8-10-22(17-20)32-2/h8-10,12-15,17-18,26,28H,4-7,11,16,19H2,1-3H3
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InChIKey
XDGZSVPHADAZSU-UHFFFAOYSA-N
Physicochemical Property
logP
5.6098
Rotatable Bonds
8
Heavy Atom Count
34
Polar Areas
71.63
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44340661
ChEMBL ID
CHEMBL325658
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 794.33 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 50.12 nM
   TI
   LI
   LO
   TS