General Information of the Compound
Compound ID
CP0520478
Compound Name
(4S)5-[4-(Ethoxycarbonyl)iperazin-1-yl]-5-oxo-4-{[(6-phenyl-4-propoxypyridin-2-yl)carbonyl]amino}pentanoic Acid
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Structure
Formula
C27H34N4O7
Molecular Weight
526.59
Canonical SMILES
CCCOc1cc(nc(c1)-c1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCN(CC1)C(=O)OCC
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InChI
InChI=1S/C27H34N4O7/c1-3-16-38-20-17-22(19-8-6-5-7-9-19)28-23(18-20)25(34)29-21(10-11-24(32)33)26(35)30-12-14-31(15-13-30)27(36)37-4-2/h5-9,17-18,21H,3-4,10-16H2,1-2H3,(H,29,34)(H,32,33)/t21-/m0/s1
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InChIKey
PUPSDODQAPCXQJ-NRFANRHFSA-N
Physicochemical Property
logP
2.8013
Rotatable Bonds
11
Heavy Atom Count
38
Polar Areas
138.37
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45142448
SID: 92392439
ChEMBL ID
CHEMBL606209
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02449, P2Y purinoceptor 12
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 120 nM
   TI
   LI
   LO
   TS