General Information of the Compound
Compound ID
CP0520432
Compound Name
(4S)5-[4-(Butoxycarbonyl)piperazin-1-yl]-5-oxo-4-({[6-phenyl-4-(2-piperidin-4-ylethoxy)pyridin-2-yl]carbonyl}amino)pentanoicAcid
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Structure
Formula
C33H45N5O7
Molecular Weight
623.751
Canonical SMILES
CCCCOC(=O)N1CCN(CC1)C(=O)[C@H](CCC(O)=O)NC(=O)c1cc(OCCC2CCNCC2)cc(n1)-c1ccccc1
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InChI
InChI=1S/C33H45N5O7/c1-2-3-20-45-33(43)38-18-16-37(17-19-38)32(42)27(9-10-30(39)40)36-31(41)29-23-26(44-21-13-24-11-14-34-15-12-24)22-28(35-29)25-7-5-4-6-8-25/h4-8,22-24,27,34H,2-3,9-21H2,1H3,(H,36,41)(H,39,40)/t27-/m0/s1
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InChIKey
HYBBGSNXJIBWBP-MHZLTWQESA-N
Physicochemical Property
logP
3.5612
Rotatable Bonds
14
Heavy Atom Count
45
Polar Areas
150.4
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
8
Complexity
45

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45139768
SID: 92389687
ChEMBL ID
CHEMBL592810
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02449, P2Y purinoceptor 12
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 3 nM
   TI
   LI
   LO
   TS