General Information of the Compound
Compound ID
CP0519712
Compound Name
3-[(3-fluorophenyl)methyl]-3-methyl-10-[4-(trifluoromethyl)phenyl]-1,4,8,12-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),7,9,11-tetraene
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Structure
Formula
C23H18F4N4
Molecular Weight
426.417
Canonical SMILES
CC1(Cc2cccc(F)c2)NCc2cnc3c(cnn3c12)-c1ccc(cc1)C(F)(F)F
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InChI
InChI=1S/C23H18F4N4/c1-22(10-14-3-2-4-18(24)9-14)20-16(12-29-22)11-28-21-19(13-30-31(20)21)15-5-7-17(8-6-15)23(25,26)27/h2-9,11,13,29H,10,12H2,1H3
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InChIKey
DGYNSEVBOQZAQV-UHFFFAOYSA-N
Physicochemical Property
logP
5.1153
Rotatable Bonds
3
Heavy Atom Count
31
Polar Areas
42.22
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118720424
ChEMBL ID
CHEMBL3354796
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02455, Glucose-dependent insulinotropic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 436 nM
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