General Information of the Compound
Compound ID
CP0513080
Compound Name
(4S)-4-[[5-[2-[3-(cyclobutylcarbamoyl)azetidin-1-yl]-2-oxoethoxy]-1-phenylpyrazole-3-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid
    Show/Hide
Structure
Formula
C32H41N7O9
Molecular Weight
667.72
Canonical SMILES
CCOC(=O)N1CCN(CC1)C(=O)[C@H](CCC(O)=O)NC(=O)c1cc(OCC(=O)N2CC(C2)C(=O)NC2CCC2)n(n1)-c1ccccc1
    Show/Hide
InChI
InChI=1S/C32H41N7O9/c1-2-47-32(46)37-15-13-36(14-16-37)31(45)24(11-12-28(41)42)34-30(44)25-17-27(39(35-25)23-9-4-3-5-10-23)48-20-26(40)38-18-21(19-38)29(43)33-22-7-6-8-22/h3-5,9-10,17,21-22,24H,2,6-8,11-16,18-20H2,1H3,(H,33,43)(H,34,44)(H,41,42)/t24-/m0/s1
    Show/Hide
InChIKey
NEOPAGBOYFPYRC-DEOSSOPVSA-N
Physicochemical Property
logP
0.6421
Rotatable Bonds
13
Heavy Atom Count
48
Polar Areas
192.71
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
10
Complexity
48

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 66854409
SID: 163457318
ChEMBL ID
CHEMBL2172159
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02449, P2Y purinoceptor 12
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 613 nM
   TI
   LI
   LO
   TS