General Information of the Compound
Compound ID
CP0507641
Compound Name
(1-{(R)-1-{3-[(E)-2-(5-Ethyl-6-methyl-pyridin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid
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Structure
Formula
C34H41NO3S
Molecular Weight
543.773
Canonical SMILES
CCc1ccc(\C=C\c2cccc(c2)[C@@H](CCc2ccccc2C(C)(C)O)SCC2(CC(O)=O)CC2)nc1C
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InChI
InChI=1S/C34H41NO3S/c1-5-26-14-17-29(35-24(26)2)16-13-25-9-8-11-28(21-25)31(39-23-34(19-20-34)22-32(36)37)18-15-27-10-6-7-12-30(27)33(3,4)38/h6-14,16-17,21,31,38H,5,15,18-20,22-23H2,1-4H3,(H,36,37)/b16-13+/t31-/m1/s1
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InChIKey
PJVNGFRHENPVNP-ILZHQVLHSA-N
Physicochemical Property
logP
8.01222
Rotatable Bonds
13
Heavy Atom Count
39
Polar Areas
70.42
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 15291439
ChEMBL ID
CHEMBL345093
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01800, Cysteinyl leukotriene receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000100 U-937 Homo sapiens (Human)  1
1
IC50 = 2.7 nM
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